TY - JOUR
T1 - Periodontal Repair in Dogs
T2 - Effect of Allogenic Freeze-Dried Demineralized Bone Matrix Implants on Alveolar Bone and Cementum Regeneration
AU - Kim, Chong Kwan
AU - Cho, Kyoo Sung
AU - Choi, Seong Ho
AU - Prewett, Annamarie
AU - Wikesjö, Ulf M E
PY - 1998/1/1
Y1 - 1998/1/1
N2 - THE OBJECTIVE OF THIS STUDY was to evaluate alveolar bone and cementum regeneration following surgical placement of an allogenic, freeze-dried, demineralized bone matrix (DBM) cortical strip implant. Critical size, supraalveolar periodontal defects were surgically created around the second, third, and fourth mandibular premolar teeth in eight mongrel dogs. Contralateral jaw quadrants in six animals were randomly assigned to receive the DBM implant, or serve as surgical control. Two additional animals received bilateral DBM implants. Flaps were coronally advanced to submerge teeth and implants, and sutured. Three animals were exited from the study due to extensive early wound failure. Remaining animals were sacrificed at 8 weeks post-surgery. Histometric recordings included defect height, bone regeneration/DBM implant height, cementum regeneration height, root resorption, and ankylosis. Large areas of unresorbed DBM exhibiting fragmentation and empty osteocyte lacunae were observed adjacent to new bone formation, or bone formation was observed adjacent to or within the implant, often exhibiting ankylosis. Cementum regeneration appeared enhanced in shelter of the DBM implant. Histometric recordings (mean ± SD) for DBM and control defects, respectively, were: defect height, 4.8 ± 0.2 mm and 4.4 ± 0.2 mm; bone regeneration/DBM implant height, 4.0 ± 1.3 mm and 1.2 ± 0.6 mm; cementum regeneration height, 1.4 ± 0.4 mm and 0.7 ± 0.2 mm; root resorption, 0.5 ± 0.3 mm and 1.2 ± 0.3 mm; and ankylosis, 0.5 ± 0.2 mm and 0.1 ± 0.1 mm without statistically significant differences between experimental conditions (N=3). Within the limitations of this study, the histologic observations suggest that surgical implantation of allogenic, freeze-dried DBM cortical strip implants may have a potential to support cementum regeneration, possibly by providing conditions for guided tissue regeneration, however, alveolar regeneration appears unpredictable.
AB - THE OBJECTIVE OF THIS STUDY was to evaluate alveolar bone and cementum regeneration following surgical placement of an allogenic, freeze-dried, demineralized bone matrix (DBM) cortical strip implant. Critical size, supraalveolar periodontal defects were surgically created around the second, third, and fourth mandibular premolar teeth in eight mongrel dogs. Contralateral jaw quadrants in six animals were randomly assigned to receive the DBM implant, or serve as surgical control. Two additional animals received bilateral DBM implants. Flaps were coronally advanced to submerge teeth and implants, and sutured. Three animals were exited from the study due to extensive early wound failure. Remaining animals were sacrificed at 8 weeks post-surgery. Histometric recordings included defect height, bone regeneration/DBM implant height, cementum regeneration height, root resorption, and ankylosis. Large areas of unresorbed DBM exhibiting fragmentation and empty osteocyte lacunae were observed adjacent to new bone formation, or bone formation was observed adjacent to or within the implant, often exhibiting ankylosis. Cementum regeneration appeared enhanced in shelter of the DBM implant. Histometric recordings (mean ± SD) for DBM and control defects, respectively, were: defect height, 4.8 ± 0.2 mm and 4.4 ± 0.2 mm; bone regeneration/DBM implant height, 4.0 ± 1.3 mm and 1.2 ± 0.6 mm; cementum regeneration height, 1.4 ± 0.4 mm and 0.7 ± 0.2 mm; root resorption, 0.5 ± 0.3 mm and 1.2 ± 0.3 mm; and ankylosis, 0.5 ± 0.2 mm and 0.1 ± 0.1 mm without statistically significant differences between experimental conditions (N=3). Within the limitations of this study, the histologic observations suggest that surgical implantation of allogenic, freeze-dried DBM cortical strip implants may have a potential to support cementum regeneration, possibly by providing conditions for guided tissue regeneration, however, alveolar regeneration appears unpredictable.
KW - Alveolar bone
KW - Bone regeneration
KW - Bone, demineralized
KW - Bone, freeze-dried
KW - Cementum
KW - Grafts, bone
KW - Periodontal diseases/therapy
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U2 - 10.1902/jop.1998.69.1.26
DO - 10.1902/jop.1998.69.1.26
M3 - Article
C2 - 9527558
AN - SCOPUS:0031608052
SN - 0022-3492
VL - 69
SP - 26
EP - 33
JO - Journal of Periodontology
JF - Journal of Periodontology
IS - 1
ER -