Periodontal repair in dogs: Effect of transforming growth factor-β1 on alveolar bone and cementum regeneration

Dimitris N. Tatakis, Ulf M E Wikesjö, Saghi S. Razi, Thorarinn J. Sigurdsson, Michael B. Lee, Tue Nguyen, Boonsri Ongpipattanakul, Ross Hardwick

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Background, aim: Transforming growth factor-β (TGF-β) represents a family of growth-modulating proteins with fundamental rôles in connective tissue and bone development. The objective of this study was to evaluate the potential for regeneration of alveolar bone and cementum following surgical implantation of recombinant human TGF-β1 (rhTGF-β1). Method: Bilateral, critical size, supra-alveolar periodontal defects in 5 beagle dogs were surgically implanted with rhTGF-β1 in a calcium carbonate carrier (CaCO3) or with carrier alone. The animals were euthanized at 4 weeks postsurgery and block-biopsies of the defects were processed for histologic and histometric analysis. Results: Surgical implantation of rhTGF-β1 resulted in minimal, if any, stimulation of alveolar bone or cementum regeneration. Linear bone and cementum regeneration in rhTGF-β1-treated defects was 1.2±0.6 and 0.01±0.01 mm, respectively. Correspondiong values for the controls were 1.0±0.6 and 0.01±0.03 mm. Conclusions. The results suggest that, under the conditions (dose, carrier, defect type) evaluated here, treatment of periodontal defects in beagle dogs with rhTGF-β1 may be of limited clinical benefit.

Original languageEnglish (US)
Pages (from-to)698-704
Number of pages7
JournalJournal of Clinical Periodontology
Issue number9
StatePublished - Sep 2000


  • Bone, cementum
  • Calcium carbonate
  • Regeneration
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Periodontics


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