Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers

Thorarinn J. Sigurdsson, Lauralee Nygaard, Dimitris N. Tatakis, Earl Fu, Thomas J. Turek, Lisa Jin, John M. Wozney, Ulf M E Wikesjö

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


This study evaluated candidate carriers for recombinant human bone morphogenetic protein-2 (rhBMP-2)-driven periodontal regeneration. Previous experiments indicated the ability of rhBMP-2 in a particulate delivery system to result In substantial regeneration of bone and periodontal attachment. In the present study, canine demineralized bone matrix (DBM). bovine deorganified crystalline bone matrix (Bio-Oss), on absorbable collagen sponge (ACS) of type I bovine collagen. poly(D,L-lactide-coglycolide) microparticles (PLGA), and polylactic acid granules (Drilac) were tested for their ability to support rhBMP-2 (0.2 mg/mL implant volume)-driven periodontal regeneration. The implants were tested in routine critical size canine supra-alveolar periodontal defects with transgingival tooth positioning. Contralateral defects in six beagle dogs were semirandomly assigned to receive: DBM/rhBMP-2. DBM (no rhBMP-2), Bio-Oss/rhBMP-2, ACS/rhBMP-2. PLGA/rhBMP-2, or Drilac/rhBMP-2. Animals were sacrificed 8 weeks postsurgery, and block sections of the defects were processed for light microscopy. Substantial bone regeneration was observed in all defects implanted with rhBMP-2. Other measures of periodontal healing. Including cementum regeneration and presence of ankylosis, were more variable between the implants. DBM and BioOss performed well as carriers for rhBMP-2-driven periodontal regeneration, although other impediments to their clinical use exist. This study indicates that qualities of the carrier system, including its space-maintaining capacity, can affect the ability of rhBMP-2 to regenerate both alveolar bone and periodontal attachment.

Original languageEnglish (US)
Pages (from-to)525-537
Number of pages13
JournalInternational Journal of Periodontics and Restorative Dentistry
Issue number6
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics


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