Peripheral clocks and the regulation of cardiovascular and metabolic function

Radu Daniel Rudic; Anne M. Curtis; Yan Cheng; Garret FitzGerald

doi:10.1016/S0076-6879(05)93027-9

Peripheral clocks and the regulation of cardiovascular and metabolic function

Radu Daniel Rudic, Anne M. Curtis, Yan Cheng, Garret FitzGerald

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Circadian rhythms generated by cell autonomous biological clocks allow for the appropriate temporal synchronization of physiology and behavior, optimizing the efficiency of biological systems. Circadian oscillators and functions have been uncovered in both central and peripheral tissues. This article describes methodology, experimental design, and technical challenges pertaining to studies of circadian rhythms in the periphery. Experimental approaches are focused upon revealing the role of peripheral clocks in cardiovascular and metabolic function using in vitro and in vivo techniques.

Original language	English (US)
Article number	27
Pages (from-to)	524-539
Number of pages	16
Journal	Methods in Enzymology
Volume	393
DOIs	https://doi.org/10.1016/S0076-6879(05)93027-9
State	Published - Jan 1 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0076-6879(05)93027-9

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abstract = "Circadian rhythms generated by cell autonomous biological clocks allow for the appropriate temporal synchronization of physiology and behavior, optimizing the efficiency of biological systems. Circadian oscillators and functions have been uncovered in both central and peripheral tissues. This article describes methodology, experimental design, and technical challenges pertaining to studies of circadian rhythms in the periphery. Experimental approaches are focused upon revealing the role of peripheral clocks in cardiovascular and metabolic function using in vitro and in vivo techniques.",

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AB - Circadian rhythms generated by cell autonomous biological clocks allow for the appropriate temporal synchronization of physiology and behavior, optimizing the efficiency of biological systems. Circadian oscillators and functions have been uncovered in both central and peripheral tissues. This article describes methodology, experimental design, and technical challenges pertaining to studies of circadian rhythms in the periphery. Experimental approaches are focused upon revealing the role of peripheral clocks in cardiovascular and metabolic function using in vitro and in vivo techniques.

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Peripheral clocks and the regulation of cardiovascular and metabolic function

Abstract

ASJC Scopus subject areas

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