Peripheral clocks and the regulation of cardiovascular and metabolic function

Radu Daniel Rudic, Anne M. Curtis, Yan Cheng, Garret FitzGerald

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Circadian rhythms generated by cell autonomous biological clocks allow for the appropriate temporal synchronization of physiology and behavior, optimizing the efficiency of biological systems. Circadian oscillators and functions have been uncovered in both central and peripheral tissues. This article describes methodology, experimental design, and technical challenges pertaining to studies of circadian rhythms in the periphery. Experimental approaches are focused upon revealing the role of peripheral clocks in cardiovascular and metabolic function using in vitro and in vivo techniques.

Original languageEnglish (US)
Article number27
Pages (from-to)524-539
Number of pages16
JournalMethods in Enzymology
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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