TY - JOUR
T1 - Perivascular adipose tissue in autoimmune rheumatic diseases
AU - Shi, Hong
AU - Wu, Hanping
AU - Winkler, Michael Alan
AU - Belin de Chantemèle, Eric J.
AU - Lee, Richard
AU - Kim, Ha Won
AU - Weintraub, Neal L.
N1 - Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - Perivascular adipose tissue (PVAT) resides at the outermost boundary of the vascular wall, surrounding most conduit blood vessels, except for the cerebral vessels, in humans. A growing body of evidence suggests that inflammation localized within PVAT may contribute to the pathogenesis of cardiovascular disease (CVD). Patients with autoimmune rheumatic diseases (ARDs), e.g., systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis, etc., exhibit heightened systemic inflammation and are at increased risk for CVD. Data from clinical studies in patients with ARDs support a linkage between dysfunctional adipose tissue, and PVAT in particular, in disease pathogenesis. Here, we review the data linking PVAT to the pathogenesis of CVD in patients with ARDs, focusing on the role of novel PVAT imaging techniques in defining disease risk and responses to biological therapies.
AB - Perivascular adipose tissue (PVAT) resides at the outermost boundary of the vascular wall, surrounding most conduit blood vessels, except for the cerebral vessels, in humans. A growing body of evidence suggests that inflammation localized within PVAT may contribute to the pathogenesis of cardiovascular disease (CVD). Patients with autoimmune rheumatic diseases (ARDs), e.g., systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis, etc., exhibit heightened systemic inflammation and are at increased risk for CVD. Data from clinical studies in patients with ARDs support a linkage between dysfunctional adipose tissue, and PVAT in particular, in disease pathogenesis. Here, we review the data linking PVAT to the pathogenesis of CVD in patients with ARDs, focusing on the role of novel PVAT imaging techniques in defining disease risk and responses to biological therapies.
KW - Adipose Tissue/physiology
KW - Autoimmune Diseases/complications
KW - Cardiovascular Diseases/pathology
KW - Humans
KW - Inflammation
KW - Respiratory Distress Syndrome
KW - Rheumatic Diseases
UR - http://www.scopus.com/inward/record.url?scp=85134667448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85134667448&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2022.106354
DO - 10.1016/j.phrs.2022.106354
M3 - Article
C2 - 35842184
AN - SCOPUS:85134667448
SN - 1043-6618
VL - 182
SP - 106354
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 106354
ER -