Perspective on fever: The basic science and conventional medicine

Joseph G. Cannon

doi:10.1016/j.ctim.2011.08.002

Perspective on fever: The basic science and conventional medicine

Joseph G. Cannon

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.

Original language	English (US)
Pages (from-to)	S54-S60
Journal	Complementary Therapies in Medicine
Volume	21
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.ctim.2011.08.002
State	Published - Apr 2013

Keywords

Cytokines
Fever
Thermoregulation

ASJC Scopus subject areas

Complementary and Manual Therapy
Complementary and alternative medicine
Advanced and Specialized Nursing

Access to Document

10.1016/j.ctim.2011.08.002

Cite this

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abstract = "This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.",

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AB - This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.

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KW - Thermoregulation

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Perspective on fever: The basic science and conventional medicine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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