PFKP signaling at a glance: An emerging mediator of cancer cell metabolism

Liwei Lang; Ron Chemmalakuzhy; Chloe Shay; Yong Teng

doi:10.1007/978-3-030-12668-1_13

PFKP signaling at a glance: An emerging mediator of cancer cell metabolism

Liwei Lang, Ron Chemmalakuzhy, Chloe Shay, Yong Teng

Oral Biology & Dx Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

40 Scopus citations

Abstract

Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	243-258
Number of pages	16
DOIs	https://doi.org/10.1007/978-3-030-12668-1_13
State	Published - 2019

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1134
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Biologic roles
Cancer
Diagnostic marker
Drug target
Gene regulations
PFKP

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-030-12668-1_13

Cite this

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abstract = "Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.",

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doi = "10.1007/978-3-030-12668-1_13",

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T2 - An emerging mediator of cancer cell metabolism

AU - Lang, Liwei

AU - Chemmalakuzhy, Ron

AU - Shay, Chloe

AU - Teng, Yong

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2019.

PY - 2019

Y1 - 2019

N2 - Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

AB - Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

KW - Biologic roles

KW - Cancer

KW - Diagnostic marker

KW - Drug target

KW - Gene regulations

KW - PFKP

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ER -

PFKP signaling at a glance: An emerging mediator of cancer cell metabolism

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

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