@article{c35a1d5b425e40019b51972937d7c499,
title = "Pharmacokinetic profile of atenolol aspirinate",
abstract = "We report microwave-assisted synthetic routes, the pharmacokinetic profile along with results from ulcerogenicity and mutagenicity studies of atenolol aspirinate, and an already described derivative, in which acetyl salicylic acid (aspirin{\textregistered}) was connected to atenolol by an ester linkage. Atenolol aspirinate was stable towards aqueous hydrolysis but rapidly hydrolyzed in plasma (t1/2 = 7.6 min). The results showed that the rapid and complete hydrolysis generates atenolol salicylate, which assumes a conformation stabilized by two intramolecular H-bonds, avoiding its further hydrolysis to salicylic acid and atenolol.",
keywords = "Antihypertensive therapy, Atenolol, Microwave synthesis, Pharmacokinetics, Prodrug",
author = "Montes-Gil, \{Ana C.\} and Marcos Zanfolin and Okuyama, \{Cristina E.\} and Sergio Lilla and Alves, \{Delma P.\} and Vincenzo Santagada and Elisa Perissutti and Antonio Lavecchia and Ferdinando Fiorino and Beatrice Severino and Giuseppe Caliendo and Fernanda Priviero and Mendes, \{Gustavo D.\} and Donato, \{Jose L.\} and \{De Nucci\}, Gilberto",
note = "Funding Information: The work described in this paper was in part, supported as part of the Esprit Me{"}sto project, the British Aerospace Dependable Computing Systems Centre and the BAe Centre of Excellence in Cockpit Automation Research. I am also indebted to John McCarthy and Pat Healey for the article that inspired some of our thinking in this paper (Healey \& McCarthy, 1997). Thanks are due to the anonymous referees who were patient enough to read a rough version of this paper and make highly constructive comments.",
year = "2007",
month = sep,
doi = "10.1002/ardp.200700070",
language = "English (US)",
volume = "340",
pages = "445--455",
journal = "Archiv der Pharmazie",
issn = "0365-6233",
publisher = "Wiley-VCH Verlag",
number = "9",
}