Pharmacologic Management of Chronic Constipation

Siddharth Singh, Satish S.C. Rao

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Chronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.

Original languageEnglish (US)
Pages (from-to)509-527
Number of pages19
JournalGastroenterology Clinics of North America
Issue number3
StatePublished - Sep 2010
Externally publishedYes


  • Alvimopan
  • Chronic constipation
  • Laxatives
  • Linaclotide
  • Lubiprostone
  • Medical management
  • Methylnaltrexone
  • Prucalopride

ASJC Scopus subject areas

  • Gastroenterology


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