Phenformin: AMP(K)ed for Potential Repurposing

Joo Jung; Wendy B. Bollag

doi:10.1016/j.jid.2020.06.008

Phenformin: AMP(K)ed for Potential Repurposing

Joo Jung
, Wendy B. Bollag

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.

Original language	English (US)
Pages (from-to)	11-14
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	141
Issue number	1
DOIs	https://doi.org/10.1016/j.jid.2020.06.008
State	Published - Jan 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2020.06.008

Cite this

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title = "Phenformin: AMP(K)ed for Potential Repurposing",

abstract = "The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.",

author = "Joo Jung and Bollag, \{Wendy B.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

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doi = "10.1016/j.jid.2020.06.008",

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T2 - AMP(K)ed for Potential Repurposing

AU - Jung, Joo

AU - Bollag, Wendy B.

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N2 - The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.

AB - The results in the article by Zhou et al. (2020) demonstrate that the antidiabetic drug phenformin inhibits skin tumor growth and promotes keratinocyte differentiation, and an underlying mechanism is also defined. In this commentary, additional potential mechanisms through which phenformin may exert its antitumorigenic effect are described. Thus, the proposed repurposing of phenformin to treat skin cancer has merit.

UR - https://www.scopus.com/pages/publications/85097480106

UR - https://www.scopus.com/pages/publications/85097480106#tab=citedBy

U2 - 10.1016/j.jid.2020.06.008

DO - 10.1016/j.jid.2020.06.008

M3 - Comment/debate

C2 - 33342506

AN - SCOPUS:85097480106

SN - 0022-202X

VL - 141

SP - 11

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 1

ER -

Phenformin: AMP(K)ed for Potential Repurposing

Abstract

UN SDGs

ASJC Scopus subject areas

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