PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte

Jian Kang Chen

doi:10.4161/auto.24230

PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte

Jian Kang Chen

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 ^pdKO/mVps34^pdKO) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.

Original language	English (US)
Pages (from-to)	923-924
Number of pages	2
Journal	Autophagy
Volume	9
Issue number	6
DOIs	https://doi.org/10.4161/auto.24230
State	Published - Jun 2013

Keywords

Aberrant autophagosome
Autophagy
Glomerulosclerosis
PIK3C3
Podocyte vacuolization
Proteinuria
VPS34

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.24230

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@article{f0d1b099e58247738a88dffc9b103669,

title = "PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte",

abstract = "The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 pdKO/mVps34pdKO) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.",

keywords = "Aberrant autophagosome, Autophagy, Glomerulosclerosis, PIK3C3, Podocyte vacuolization, Proteinuria, VPS34",

author = "Chen, {Jian Kang}",

note = "Funding Information: This work was supported by funds from National American Heart Association Scientist Development grant 0630274N, Vanderbilt Diabetes Research and Training Center Pilot and Feasibility grant 2P60DK020593, academic program support funds from the Department of Medicine at Vanderbilt University, startup funds from Georgia Regents University Augusta, and National Institutes of Health R01 grant DK83575 (to J.-K.C.).",

year = "2013",

month = jun,

doi = "10.4161/auto.24230",

language = "English (US)",

volume = "9",

pages = "923--924",

journal = "Autophagy",

issn = "1554-8627",

publisher = "Landes Bioscience",

number = "6",

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T1 - PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte

AU - Chen, Jian Kang

N1 - Funding Information: This work was supported by funds from National American Heart Association Scientist Development grant 0630274N, Vanderbilt Diabetes Research and Training Center Pilot and Feasibility grant 2P60DK020593, academic program support funds from the Department of Medicine at Vanderbilt University, startup funds from Georgia Regents University Augusta, and National Institutes of Health R01 grant DK83575 (to J.-K.C.).

PY - 2013/6

Y1 - 2013/6

N2 - The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 pdKO/mVps34pdKO) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.

AB - The mammalian homolog of yeast Vps34 (PIK3C3/VPS34) is implicated in the regulation of autophagy, and recent studies have suggested that autophagy is a key mechanism in maintaining the integrity of renal glomerular podocytes. To date, however, the role of PIK3C3 in podocytes has remained unknown. We generated a line of podocyte-specific Pik3c3-knockout (Pik3c3 pdKO/mVps34pdKO) mice and demonstrated an indispensable role for PIK3C3 in the regulation of intracellular vesicle trafficking and processing to protect the normal cellular metabolism, structure and function of podocytes.

KW - Aberrant autophagosome

KW - Autophagy

KW - Glomerulosclerosis

KW - PIK3C3

KW - Podocyte vacuolization

KW - Proteinuria

KW - VPS34

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DO - 10.4161/auto.24230

M3 - Article

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SN - 1554-8627

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JO - Autophagy

JF - Autophagy

IS - 6

ER -

PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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