TY - JOUR
T1 - Plasma membrane phospholipid and cholesterol distribution of skin fibroblasts from drug-naive patients at the onset of psychosis
AU - Mahadik, Sahebarao P.
AU - Mukherjee, Sukdeb
AU - Correnti, Elizabeth E.
AU - Kelkar, Hemant S.
AU - Wakade, Chandramohan G.
AU - Costa, Richard M.
AU - Scheffer, R.
N1 - Funding Information:
This research was supported in part by NIMH grants MH 41961, 46546 and 47002.
PY - 1994/10
Y1 - 1994/10
N2 - Contents of plasma membrane major phospholipids, cholesterol, and cholesteryl esters of fibroblasts from drug-naive psychotic patients were compared with those from normal controls. Total membrane lipids were extracted and individual lipids were separated on high-performance thin-layer chromatography. The contents of lipid bands were quantitated by densitometric scanning and comparing with standards. Contents of total phospholipids as well as phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine were significantly lower in fibroblasts from patients than in those from normal controls (P<0.001, <0.005, <0.05, <0.05 respectively). Total cholesterol fraction and cholesteryl esters were also significantly lower in fibroblasts from patient (P <0.005, <0.001 respectively). These changes were not related to differences in age or sex. These data support the hypothesis that schizophrenia is associated with disordered membrane lipid metabolism, and that this predates the onset of psychosis.
AB - Contents of plasma membrane major phospholipids, cholesterol, and cholesteryl esters of fibroblasts from drug-naive psychotic patients were compared with those from normal controls. Total membrane lipids were extracted and individual lipids were separated on high-performance thin-layer chromatography. The contents of lipid bands were quantitated by densitometric scanning and comparing with standards. Contents of total phospholipids as well as phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine were significantly lower in fibroblasts from patients than in those from normal controls (P<0.001, <0.005, <0.05, <0.05 respectively). Total cholesterol fraction and cholesteryl esters were also significantly lower in fibroblasts from patient (P <0.005, <0.001 respectively). These changes were not related to differences in age or sex. These data support the hypothesis that schizophrenia is associated with disordered membrane lipid metabolism, and that this predates the onset of psychosis.
KW - Cholesterol
KW - Fibroblast
KW - Plasma membrane phospholipid
KW - Psychosis
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U2 - 10.1016/0920-9964(94)90048-5
DO - 10.1016/0920-9964(94)90048-5
M3 - Article
C2 - 7841137
AN - SCOPUS:0027978180
SN - 0920-9964
VL - 13
SP - 239
EP - 247
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 3
ER -