Plasma-soluble interleukin-2 and transferrin receptor in schizoprenia and major depression

M. Maes, H. Y. Meltzer, P. Buckley, E. Bosmans

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


This study was carried out to examine some components of in vivo immune function in major depression and schizophrenia. Toward this end, plasma concentrations of interleukin-1β (IL-1β) and IL-6, soluble IL-2 receptor (sIL-2R), and transferrin receptor (TfR) were measured in 28 normal controls, 11 schizophrenics and 13 major-depressed patients. Schizophrenic and major-depressed patients showed significantly higher plasma sIL-2R and TfR than normal controls. There was a trend toward higher plasma IL-6 in the psychiatric patients, and particularly in schizophrenic patients, than in normal volunteers. In normal controls and in the total study group, there were highly significant and positive correlations between plasma TfR and sIL-2R concentrations. It is suggested that schizophrenia and major depression are characterized by immune disorders that may indicate activation of cell-mediated immunity such as T-cell activation.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number6
StatePublished - Feb 1995


  • Cytokines
  • Depression
  • Interleukin-1β Interleukin-2
  • Interleukin-6
  • Psychoimmunology
  • Schizophrenia
  • Transferrin receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)


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