Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan; Ellen Parker; Patricia V Schoenlein; Jimmie Northey; Bert Ely; Joseph F. John

doi:10.1016/S0196-6553(80)80026-5

Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Charles S. Bryan, Ellen Parker, Patricia V Schoenlein, Jimmie Northey, Bert Ely, Joseph F. John

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

Original language	English (US)
Pages (from-to)	65-71
Number of pages	7
Journal	American Journal of Infection Control
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/S0196-6553(80)80026-5
State	Published - Jan 1 1980
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0196-6553(80)80026-5

Cite this

@article{cb94784a11154a0eabdba7cf02c6c48c,

title = "Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures",

abstract = "A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.",

author = "Bryan, {Charles S.} and Ellen Parker and Schoenlein, {Patricia V} and Jimmie Northey and Bert Ely and John, {Joseph F.}",

year = "1980",

month = jan,

day = "1",

doi = "10.1016/S0196-6553(80)80026-5",

language = "English (US)",

volume = "8",

pages = "65--71",

journal = "American Journal of Infection Control",

issn = "0196-6553",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Plasmid-mediated antibiotic resistance in a changing hospital environment

T2 - Efficacy of control measures

AU - Bryan, Charles S.

AU - Parker, Ellen

AU - Schoenlein, Patricia V

AU - Northey, Jimmie

AU - Ely, Bert

AU - John, Joseph F.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

AB - A cross-transmission outbreak of gentamicin-resistant Serratia marcescens infection, followed by smaller outbreaks of gentamicin-resistant Klebsiella pneumoniae and Providentia rettgeri infection, occurred in a Veterans Administration hospital that was in the process of becoming a major teaching hospital within a new medical school. The resistant Serratia isolates carried a single plasmid, which was found only occasionally in other gentamicin-resistant bacterial species. Amikacin-resistant Serratia marcescens emerged despite infrequent use of amikacin. Environmental contamination with gentamicin-resistant Serratia was documented, in one instance, on the day following transfer of all patients in the hospital to a new facility. Control measures were thought to be responsible, at least in part, for the eventual decline in frequency of gentamicin-resistant bacteria.

UR - http://www.scopus.com/inward/record.url?scp=84908717075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908717075&partnerID=8YFLogxK

U2 - 10.1016/S0196-6553(80)80026-5

DO - 10.1016/S0196-6553(80)80026-5

M3 - Article

AN - SCOPUS:84908717075

SN - 0196-6553

VL - 8

SP - 65

EP - 71

JO - American Journal of Infection Control

JF - American Journal of Infection Control

IS - 3

ER -

Plasmid-mediated antibiotic resistance in a changing hospital environment: Efficacy of control measures

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this