Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype

Richard G Jung; Anne-Claire Duchez; Trevor Simard; Shan Dhaliwal; Taylor Gillmore; Pietro Di Santo; Alisha Labinaz; F Daniel Ramirez; Adil Rasheed; Sabrina Robichaud; Mireille Ouimet; Spencer Short; Cole Clifford; Fengxia Xiao; Marie Lordkipanidzé; Dylan Burger; Suresh Gadde; Katey J Rayner; Benjamin Hibbert

doi:10.1016/j.jacbts.2022.05.002

Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype

Richard G Jung
, Anne-Claire Duchez
, Trevor Simard
, Shan Dhaliwal
, Taylor Gillmore
, Pietro Di Santo
, Alisha Labinaz
, F Daniel Ramirez
, Adil Rasheed
, Sabrina Robichaud
, Mireille Ouimet
, Spencer Short
, Cole Clifford
, Fengxia Xiao
, Marie Lordkipanidzé
, Dylan Burger
, Suresh Gadde
, Katey J Rayner
, Benjamin Hibbert

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.

Original language	English (US)
Pages (from-to)	985-997
Number of pages	13
Journal	JACC: Basic to Translational Science
Volume	7
Issue number	10
DOIs	https://doi.org/10.1016/j.jacbts.2022.05.002
State	Published - Oct 2022

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Jung, R. G., Duchez, A.-C., Simard, T., Dhaliwal, S., Gillmore, T., Di Santo, P., Labinaz, A., Ramirez, F. D., Rasheed, A., Robichaud, S., Ouimet, M., Short, S., Clifford, C., Xiao, F., Lordkipanidzé, M., Burger, D., Gadde, S., Rayner, K. J., & Hibbert, B. (2022). Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype. JACC: Basic to Translational Science, 7(10), 985-997. https://doi.org/10.1016/j.jacbts.2022.05.002

Jung, RG, Duchez, A-C, Simard, T, Dhaliwal, S, Gillmore, T, Di Santo, P, Labinaz, A, Ramirez, FD, Rasheed, A, Robichaud, S, Ouimet, M, Short, S, Clifford, C, Xiao, F, Lordkipanidzé, M, Burger, D, Gadde, S, Rayner, KJ & Hibbert, B 2022, 'Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype', JACC: Basic to Translational Science, vol. 7, no. 10, pp. 985-997. https://doi.org/10.1016/j.jacbts.2022.05.002

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abstract = "Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.",

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AU - Gillmore, Taylor

AU - Di Santo, Pietro

AU - Labinaz, Alisha

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AB - Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.

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Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype

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