Polycystic ovary syndrome: An ancient disorder?

Ricardo Azziz, Daniel A. Dumesic, Mark O. Goodarzi

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races.

Original languageEnglish (US)
Pages (from-to)1544-1548
Number of pages5
JournalFertility and sterility
Issue number5
StatePublished - Apr 2011
Externally publishedYes


  • PCOS
  • evolution
  • susceptibility genes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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