Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction

Jun ting Gu, Kai Jiao, Jing Li, Jian fei Yan, Kai yan Wang, Fu Wang, Yan Liu, Franklin R. Tay, Ji hua Chen, Li na Niu

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Post-extraction bleeding and alveolar bone resorption are the two frequently encountered complications after tooth extraction that result in poor healing and rehabilitation difficulties. The present study covalently bonded polyphosphate onto a collagen scaffold (P-CS) by crosslinking. The P-CS demonstrated improved hemostatic property in a healthy rat model and an anticoagulant-treated rat model. This improvement is attributed to the increase in hydrophilicity, increased thrombin generation, platelet activation and stimulation of the intrinsic coagulation pathway. In addition, the P-CS promoted the in-situ bone regeneration and alveolar ridge preservation in a rat alveolar bone defect model. The promotion is attributed to enhanced osteogenic differentiation of bone marrow stromal cells. Osteogenesis was improved by both polyphosphate and blood clots. Taken together, P-CS possesses favorable hemostasis and alveolar ridge preservation capability. It may be used as an effective treatment option for post-extraction bleeding and alveolar bone loss. Statement of significance: Collagen scaffold is commonly used for the treatment of post-extraction bleeding and alveolar bone loss after tooth extraction. However, its application is hampered by insufficient hemostatic and osteoinductive property. Crosslinking polyphosphate with collagen produces a modified collagen scaffold that possesses improved hemostatic performance and augmented bone regeneration potential.

Original languageEnglish (US)
Pages (from-to)68-81
Number of pages14
JournalBioactive Materials
StatePublished - Sep 2022


  • Alveolar ridge preservation
  • Blood clotting
  • Osteogenesis
  • Polyphosphate

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biomedical Engineering


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