Postprandial effects on electrolyte homeostasis in the kidney

Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na⁺ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na⁺ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na⁺ reabsorption in the kidney and the role of the epithelial Na⁺ channels as an important channel contributing to insulin-mediated Na⁺ reclamation.