Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

David H. Munn; Madhav D. Sharma; Jeffrey R. Lee; Kanchan G. Jhaver; Theodore S. Johnson; Derin B. Keskin; Brendan Marshall; Phillip Chandler; Scott J. Antonia; Russell Burgess; Craig L. Slingluff; Andrew L. Mellor

doi:10.1126/science.1073514

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

David H. Munn
, Madhav D. Sharma
, Jeffrey R. Lee
, Kanchan G. Jhaver
, Theodore S. Johnson
, Derin B. Keskin
, Brendan Marshall
, Phillip Chandler
, Scott J. Antonia
, Russell Burgess
, Craig L. Slingluff
, Andrew L. Mellor

Research output: Contribution to journal › Article › peer-review

938 Scopus citations

Abstract

Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123⁺ DCs. IDO⁺ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

Original language	English (US)
Pages (from-to)	1867-1870
Number of pages	4
Journal	Science
Volume	297
Issue number	5588
DOIs	https://doi.org/10.1126/science.1073514
State	Published - Sep 13 2002

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title = "Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase",

abstract = "Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.",

author = "Munn, \{David H.\} and Sharma, \{Madhav D.\} and Lee, \{Jeffrey R.\} and Jhaver, \{Kanchan G.\} and Johnson, \{Theodore S.\} and Keskin, \{Derin B.\} and Brendan Marshall and Phillip Chandler and Antonia, \{Scott J.\} and Russell Burgess and Slingluff, \{Craig L.\} and Mellor, \{Andrew L.\}",

year = "2002",

month = sep,

day = "13",

doi = "10.1126/science.1073514",

language = "English (US)",

volume = "297",

pages = "1867--1870",

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TY - JOUR

T1 - Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

AU - Munn, David H.

AU - Sharma, Madhav D.

AU - Lee, Jeffrey R.

AU - Jhaver, Kanchan G.

AU - Johnson, Theodore S.

AU - Keskin, Derin B.

AU - Marshall, Brendan

AU - Chandler, Phillip

AU - Antonia, Scott J.

AU - Burgess, Russell

AU - Slingluff, Craig L.

AU - Mellor, Andrew L.

PY - 2002/9/13

Y1 - 2002/9/13

N2 - Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

AB - Antigen-presenting cells (APCS) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

UR - https://www.scopus.com/pages/publications/18544364477

UR - https://www.scopus.com/pages/publications/18544364477#tab=citedBy

U2 - 10.1126/science.1073514

DO - 10.1126/science.1073514

M3 - Article

C2 - 12228717

AN - SCOPUS:18544364477

SN - 0036-8075

VL - 297

SP - 1867

EP - 1870

JO - Science

JF - Science

IS - 5588

ER -

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

Abstract

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