TY - JOUR
T1 - Potentiation of Purified Erythropoietin with Serum Proteins. II
T2 - Serial Dose Response Relationships
AU - Moores, Russell R.
AU - Gardner, Edward
AU - Wright, Claude Starr
AU - Lewis, Jasper P.
N1 - Funding Information:
This investigation supported in part by USPHS Grants AM 07705-03 and CA 0552 5-04, Nat. Inst. of Arthritis and Metab. Dis. and Nat. Cancer Inst. 11 1966 123 2 618 620
PY - 1966/11
Y1 - 1966/11
N2 - Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.
AB - Erythropoietin (urinary fraction II + III) was diluted with either saline or normal serum and injected into assay animals as a single dose or as 2 or 4 fractional doses either intraperitoneally or subcutaneously. Erythropoietic activity increased as the dose was fractionated; however, the erythropoietin plus serum showed greater activity than erythropoietin plus saline in all dosage schedules. This suggests that normal serum actually enhances the activity of erythropoietin rather than merely acting as an adjuvant causing delayed absorption of the material. Grateful acknowledgement is made to Miss Bettie Williams and Mrs. Carol Cope for fine technical assistance, to Dr. Charles B. Bragassa, Mrs. Rebecca Bedingfield and Mr. Bob Ellis of the Computer Center, Medical College of Georgia, for statistical analyses and to Mrs. Margaret Hiers and Mrs. Shirl Melton for secretarial assistance.
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U2 - 10.3181/00379727-123-31560
DO - 10.3181/00379727-123-31560
M3 - Article
C2 - 5924511
AN - SCOPUS:0013973385
SN - 0037-9727
VL - 123
SP - 618
EP - 620
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -