TY - JOUR
T1 - Potentiation of the 5-hydroxytryptamine-induced increases in myocardial contractility in Mercenaria mercenaria ventricle by forskolin
AU - Paciotti, Giulio Franco
AU - Higgins, William J.
PY - 1985
Y1 - 1985
N2 - 1. Forskolin (10-5 M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. 2. Forskolin (10-5 M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. 3. Ro 20-1724 (10-5 M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. 4. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.
AB - 1. Forskolin (10-5 M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. 2. Forskolin (10-5 M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. 3. Ro 20-1724 (10-5 M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. 4. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.
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U2 - 10.1016/0742-8413(85)90064-7
DO - 10.1016/0742-8413(85)90064-7
M3 - Article
C2 - 2861017
AN - SCOPUS:0021983571
SN - 0306-4492
VL - 80
SP - 325
EP - 329
JO - Comparative Biochemistry and Physiology. Part C, Comparative
JF - Comparative Biochemistry and Physiology. Part C, Comparative
IS - 2
ER -