TY - JOUR
T1 - Predictive value and changes of renin secretion in hypertensive patients with unilateral renovascular disease undergoing successful renal angioplasty
AU - Pickering, Thomas G.
AU - Sos, Thomas A.
AU - Vaughan, E. Darracott
AU - Case, David B.
AU - Sealey, Jean E.
AU - Harshfield, Gregory A.
AU - Laragh, John H.
N1 - Funding Information:
THOMAS G. PICKERING, M.D., D.Phil. THOMAS A. SOS, M.D. E. DARRACOTT VAUGHAN, Jr., M.D. DAVID B. CASE, M.D. JEAN E. SEALEY, DSc. GREGORY A. HARSHFIELD, Ph.D. JOHN H. LARAGH, M.D. New York, New York From the Cardiovascular Center and Division of Cardiovascular Radiology, New York Hospital-Cornell University Medical College, New York, New York. This work was supported in part by United States Public Health Service Grants 5P50-HL18323 SCOR and lK04-HL01090 (Dr. Harshfield). Requests for reprints should be addressed to Dr. Thomas G. Pickering, New York Hospital-Cornell University Medical Center, Cardiovascular Center, K-400,525 East 68th Street, New York, New York 10021. Manuscript accepted September 6, 1983.
PY - 1984/3
Y1 - 1984/3
N2 - Peripheral and renal vein renin activity was measured in 46 hypertensive patients with arteriographically diagnosed unilateral renal artery stenosis before and six months after technically successful renal angioplasty. The renin-sodium profile was high in 80 percent before angioplasty, fell in all patients, and became normal or low in 85 percent after angioplasty. Renal vein renin activity, which initially showed lateralization of renin secretion to the ischemic kidney with contralateral suppression, became normal. Renal vein renin activity was more reliable for predicting the therapeutic response when expressed as the increment of renin for each renal vein over the infrarenal vena caval value (sensitivity 74 percent, specificity 100 percent) than as the ratio between the two renal veins (sensitivity 62 percent, specificity 60 percent). The predictive value of renal vein renin activity is poor when plasma renin activity is stimulated by long-term administration of captopril. These data support the usefulness and define the limitations of peripheral and renal vein renin measurements in selecting patients for treatment by renal angioplasty.
AB - Peripheral and renal vein renin activity was measured in 46 hypertensive patients with arteriographically diagnosed unilateral renal artery stenosis before and six months after technically successful renal angioplasty. The renin-sodium profile was high in 80 percent before angioplasty, fell in all patients, and became normal or low in 85 percent after angioplasty. Renal vein renin activity, which initially showed lateralization of renin secretion to the ischemic kidney with contralateral suppression, became normal. Renal vein renin activity was more reliable for predicting the therapeutic response when expressed as the increment of renin for each renal vein over the infrarenal vena caval value (sensitivity 74 percent, specificity 100 percent) than as the ratio between the two renal veins (sensitivity 62 percent, specificity 60 percent). The predictive value of renal vein renin activity is poor when plasma renin activity is stimulated by long-term administration of captopril. These data support the usefulness and define the limitations of peripheral and renal vein renin measurements in selecting patients for treatment by renal angioplasty.
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U2 - 10.1016/0002-9343(84)90657-0
DO - 10.1016/0002-9343(84)90657-0
M3 - Article
C2 - 6230933
AN - SCOPUS:0021327147
SN - 0002-9343
VL - 76
SP - 398
EP - 404
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 3
ER -