Preferential loss of maternal alleles in sporadic Wilms' tumour

Niklas Pal; Roy B. Wadey; Brenda Buckle; Elizabeth Yeomans; Jon Pritchard; John K. Cowell

Preferential loss of maternal alleles in sporadic Wilms' tumour

Niklas Pal, Roy B. Wadey, Brenda Buckle, Elizabeth Yeomans, Jon Pritchard, John K. Cowell

Research output: Contribution to journal › Article › peer-review

Abstract

Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms' tumour.

Original language	English (US)
Pages (from-to)	1665-1668
Number of pages	4
Journal	Oncogene
Volume	5
Issue number	11
State	Published - Nov 1990
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Preferential loss of maternal alleles in sporadic Wilms' tumour",

abstract = "Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms' tumour.",

author = "Niklas Pal and Wadey, {Roy B.} and Brenda Buckle and Elizabeth Yeomans and Jon Pritchard and Cowell, {John K.}",

year = "1990",

month = nov,

language = "English (US)",

volume = "5",

pages = "1665--1668",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

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T1 - Preferential loss of maternal alleles in sporadic Wilms' tumour

AU - Pal, Niklas

AU - Wadey, Roy B.

AU - Buckle, Brenda

AU - Yeomans, Elizabeth

AU - Pritchard, Jon

AU - Cowell, John K.

PY - 1990/11

Y1 - 1990/11

N2 - Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms' tumour.

AB - Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms' tumour.

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M3 - Article

C2 - 1980007

AN - SCOPUS:0025227901

SN - 0950-9232

VL - 5

SP - 1665

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JO - Oncogene

JF - Oncogene

IS - 11

ER -

Preferential loss of maternal alleles in sporadic Wilms' tumour

Abstract

ASJC Scopus subject areas

UN SDGs

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