Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type

K. Meador, D. Loring, M. Nichols, E. Zamrini, M. Rivner, H. Posas, E. Thompson, E. Moore

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Thiamine is important not only in the metabolism of acetylcholine but also in its release from the presynaptic neuron. Pathologic, clinical, and biochemical data suggest that thiamine deficiency is detrimental to the cholinergic system and that thiamine-dependent enzymes may be altered in Alzheimer's disease. Two previous studies reported contradictory results in patients with dementia of Alzheimer's type treated with 3 g/day of thiamine. In the present study, we examined the effects of 3 to 8 g/day thiamine administered orally. Our results suggest that thiamine at these pharmacologic dosages may have a mild beneficial effect in dementia of Alzheimer's type. The mechanism of the observed effect is unknown, but the findings warrant further investigation, not only for their therapeutic implications but for their possible etiologic clues. In addition, the results suggest long-term carry-over effects that should be considered in the design of future studies.

Original languageEnglish (US)
Pages (from-to)222-229
Number of pages8
JournalJournal of Geriatric Psychiatry and Neurology
Issue number4
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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