@article{37b9358b651a44d782d9a68f1ae9b9d1,
title = "Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial",
abstract = "Objectives: The natural history of human papillomavirus (HPV) infection has been studied extensively in young women; this study investigated HPV infection in adult women. Methods: Data from 3817 women aged 24–45 years in a global trial of the 4-valent HPV (6/11/16/18) vaccine were used to calculate prevalence of anogenital infections containing 9-valent (9v) HPV vaccine types (6/11/16/18/31/33/45/52/58) and five non-vaccine types (35/39/51/56/59). Incidence of infections and persistent infections was estimated for 989 placebo recipients naive to all 14 HPV types at baseline. Age-adjusted hazard ratios were calculated for various sociodemographic factors. Results: Prevalence of anogenital infection was highest in France at 29.2% (9vHPV types) and 21.7% (non-vaccine types) and lowest in the Philippines at 7.6% (9vHPV types) and 5.1% (non-vaccine types). Overall, HPV incidence (per 100 person-years) was 5.2 (9vHPV types) and 4.7 (non-vaccine types), and incidence of persistent infection was 2.7 (9vHPV types) and 2.1 (non-vaccine types). Factors associated with new HPV infections included younger age, younger age at first intercourse, being single, current use of tobacco, and higher number of past and recent sex partners. Conclusions: Because mid-adult women acquire new HPV infections, administration of the 9vHPV vaccine could reduce HPV-related morbidity and mortality in this population.",
keywords = "Adult women, HPV vaccine, Human papillomavirus, Incidence, Persistent infection, Risk factor",
author = "Ferris, {Daron G.} and Brown, {Darron R.} and Giuliano, {Anna R.} and Evan Myers and Joura, {Elmar A.} and Garland, {Suzanne M.} and Kjaer, {Susanne K.} and Gonzalo Perez and Alfred Saah and Alain Luxembourg and Christine Velicer",
note = "Funding Information: D.G.F. reports grant support from Merck & Co., Inc. (Kenilworth, NJ) through his institution and personal fees for consultancy and advisory boards for Merck & Co., Inc.; D.R.B. reports grant support from Merck & Co., Inc. and a portion of funds from a confidential agreement with his institution and Merck & Co., Inc. as income; A.R.G. reports grant support from and is an advisory board member for Merck & Co., Inc; E.M. reports personal fees from Merck & Co., Inc.; E.A.J. reports grant support and personal fees from Merck & Co., Inc.; S.M.G. reports grant support and personal fees from and is a global advisory board member for Merck & Co., Inc.; S.K.K. reports grant support and personal fees from Merck & Co., Inc.; A.S., A.L., and C.V. are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA, and hold shares in Merck & Co., Inc., Kenilworth, NJ, USA. G.P. previously was an employee of and is currently a paid consultant for Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA, for the development of this manuscript. Funding Information: The authors would like to thank Brady Dubin, Kathy Harkins, Se Li, Mary Ann Rutkowski, Weifeng Xu, and Xingshu Zhu for their logistical and statistical programming support. Medical writing assistance was provided by ApotheCom (New York, NY, USA) and was funded by Merck Sharp & Dohme Corp ., a subsidiary of Merck & Co., Inc. , Kenilworth, NJ, USA. Funding Information: Funding for this research was provided by Merck Sharp & Dohme Corp ., a subsidiary of Merck & Co., Inc. , Kenilworth, NJ, USA. This study was designed, managed, and analyzed jointly by authors employed by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. and external authors who were not paid for their work. Medical writing assistance was provided by ApotheCom (New York, NY, USA) and was funded by Merck Sharp & Dohme Corp ., a subsidiary of Merck & Co., Inc. , Kenilworth, NJ, USA. Publisher Copyright: {\textcopyright} 2020 The Authors Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1016/j.pvr.2020.100202",
language = "English (US)",
volume = "10",
journal = "Papillomavirus Research",
issn = "2405-8521",
publisher = "Elsevier BV",
}