TY - JOUR
T1 - Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men
AU - Goldstone, Stephen
AU - Palefsky, Joel M.
AU - Giuliano, Anna R.
AU - Moreira, Edson D.
AU - Aranda, Carlos
AU - Jessen, Heiko
AU - Hillman, Richard J.
AU - Ferris, Daron G.
AU - Coutlee, Francois
AU - Liaw, Kai Li
AU - Marshall, J. Brooke
AU - Zhang, Xuehong
AU - Vuocolo, Scott
AU - Barr, Eliav
AU - Haupt, Richard M.
AU - Guris, Dalya
AU - Garner, Elizabeth I.O.
N1 - Funding Information:
Potential conflicts of interest: EDM, DGF, ARG, and JMP have received research grants from Merck, either personally or through their institution. DGF has received research grants from GlaxoSmithKline. ARG, SG, DGF, RJH, and EDM have received honoraria from Merck for speaking engagements or board membership. SG, ARG, DGF, JMP, and EDM have received travel reimbursement from Merck related to scientific meetings. CA has an approved, filed, or pending patent related to subject matter discussed in this manuscript. EIOG, EB, RMH, DG, JBM, KLL, and SV are employees of Merck and may own Merck stock and/or stock options.
Funding Information:
This work was supported by Merck.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with ≤5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/ perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.
AB - Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with ≤5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/ perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.
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U2 - 10.1093/infdis/jiq016
DO - 10.1093/infdis/jiq016
M3 - Article
C2 - 21148498
AN - SCOPUS:79851500696
SN - 0022-1899
VL - 203
SP - 66
EP - 74
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -
