Abstract
In the previous volume, we discussed the roles of primary cilia as mechanosensory organelles. Primary cilia have also been proposed to be chemosensory organelles. As a mechanosensory organelle, primary cilium could initiate the release of various cytokines-like substances, involving nitric oxide and purinergic agonists. As a chemosensory organelle, primary cilium also contains various receptors responding to hedgehog and Wnt signaling systems. In this section, we will describe cilia as newly recognized communication devices in response to agonist to regulate cell cycle and cellular development.
Original language | English (US) |
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Title of host publication | Mechanical Stretch and Cytokines |
Publisher | Springer Netherlands |
Pages | 201-222 |
Number of pages | 22 |
ISBN (Electronic) | 9789400720046 |
ISBN (Print) | 9789400720039 |
DOIs | |
State | Published - Jan 1 2012 |
Externally published | Yes |
Keywords
- Basal body
- Centriole
- Centrosome
- Primary cilium
- Shear stress
- Signal transduction
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology