Primary Extra-Pleura Leiomyoma: A Case Report and Literature Review

Asad Ullah, G. Taylor Patterson, Intisar Ghleilib, Islam A. Elhelf, Nikhil G. Patel, Nagla A. Karim

Research output: Contribution to journalArticlepeer-review


Leiomyomas are a common type of benign soft tissue tumor arising from smooth muscle, most often occurring within females’ genitourinary and gastrointestinal tract. However, primary leiomyomas of the chest wall residing in the extra-pleural space are an extremely rare subset of leiomyomatous lesion presentation. We present a case of a fifty-two-year-old male who initially presented complaining of dyspnea worsening with exertion. Computed tomography imaging was performed showing an extra-pleural mass residing under the left sixth rib. Subsequent core needle biopsy and immunohistochemical staining were performed, and the definitive diagnosis of primary leiomyoma of the posterior mediastinal chest wall. Although extremely rare, this neoplastic condi-tion should be included in your differential diagnosis when diagnostic imaging reveals a benign mass residing in the extra-pleural space, and subsequent biopsy specimens consist of smooth muscle fibers.

Original languageEnglish (US)
Pages (from-to)2935-2940
Number of pages6
JournalCurrent Oncology
Issue number5
StatePublished - May 2022


  • computed tomography
  • leiomyoma
  • pleural tumor

ASJC Scopus subject areas

  • Oncology


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