Abstract
The primary sequence of two components of the dystrophin-glycoprotein complex has been established by complementary DNA cloning. The transmembrane 43K and extracellular 156K dystrophin-associated glycoproteins (DAGs) are encoded by a single messenger RNA and the extracellular 156K DAG binds laminin. Thus, the 156K DAG is a new laminin-binding glycoprotein which may provide a linkage between the sarcolemma and extracellular matrix. These results support the hypothesis that the dramatic reduction in the 156K DAG in Duchenne muscular dystrophy leads to a loss of a linkage between the sarcolemma and extracellular matrix and that this may render muscle fibres more susceptible to necrosis.
Original language | English (US) |
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Pages (from-to) | 696-702 |
Number of pages | 7 |
Journal | Nature |
Volume | 355 |
Issue number | 6362 |
State | Published - Feb 20 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General