Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Shogo Mori; Keshav K. Nepal; Gilbert T. Kelly; Vasudha Sharma; Dinesh Simkhada; Vishruth Gowda; Dioscar Delgado; Coran M.H. Watanabe

doi:10.1021/acs.biochem.6b01108

Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Shogo Mori, Keshav K. Nepal, Gilbert T. Kelly, Vasudha Sharma, Dinesh Simkhada, Vishruth Gowda, Dioscar Delgado, Coran M.H. Watanabe

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

Original language	English (US)
Pages (from-to)	805-808
Number of pages	4
Journal	Biochemistry
Volume	56
Issue number	6
DOIs	https://doi.org/10.1021/acs.biochem.6b01108
State	Published - Feb 14 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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10.1021/acs.biochem.6b01108

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abstract = "The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.",

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note = "Funding Information: We are grateful to the National Science Foundation (CHE- 1608580) and the Welch Foundation (A-1828) for financial support. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acs.biochem.6b01108",

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AU - Mori, Shogo

AU - Nepal, Keshav K.

AU - Kelly, Gilbert T.

AU - Sharma, Vasudha

AU - Simkhada, Dinesh

AU - Gowda, Vishruth

AU - Delgado, Dioscar

AU - Watanabe, Coran M.H.

N1 - Funding Information: We are grateful to the National Science Foundation (CHE- 1608580) and the Welch Foundation (A-1828) for financial support. Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/2/14

Y1 - 2017/2/14

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AB - The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

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Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Abstract

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