Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Shogo Mori; Keshav K. Nepal; Gilbert T. Kelly; Vasudha Sharma; Dinesh Simkhada; Vishruth Gowda; Dioscar Delgado; Coran M.H. Watanabe

doi:10.1021/acs.biochem.6b01108

Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Shogo Mori
, Keshav K. Nepal
, Gilbert T. Kelly
, Vasudha Sharma
, Dinesh Simkhada
, Vishruth Gowda
, Dioscar Delgado
, Coran M.H. Watanabe

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

Original language	English (US)
Pages (from-to)	805-808
Number of pages	4
Journal	Biochemistry
Volume	56
Issue number	6
DOIs	https://doi.org/10.1021/acs.biochem.6b01108
State	Published - Feb 14 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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10.1021/acs.biochem.6b01108

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title = "Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents",

abstract = "The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.",

author = "Shogo Mori and Nepal, \{Keshav K.\} and Kelly, \{Gilbert T.\} and Vasudha Sharma and Dinesh Simkhada and Vishruth Gowda and Dioscar Delgado and Watanabe, \{Coran M.H.\}",

note = "Funding Information: We are grateful to the National Science Foundation (CHE- 1608580) and the Welch Foundation (A-1828) for financial support. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acs.biochem.6b01108",

language = "English (US)",

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AU - Mori, Shogo

AU - Nepal, Keshav K.

AU - Kelly, Gilbert T.

AU - Sharma, Vasudha

AU - Simkhada, Dinesh

AU - Gowda, Vishruth

AU - Delgado, Dioscar

AU - Watanabe, Coran M.H.

N1 - Funding Information: We are grateful to the National Science Foundation (CHE- 1608580) and the Welch Foundation (A-1828) for financial support. Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/2/14

Y1 - 2017/2/14

N2 - The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

AB - The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

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EP - 808

JO - Biochemistry

JF - Biochemistry

IS - 6

ER -

Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Abstract

ASJC Scopus subject areas

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