Principles and mechanisms of peri-implant soft tissue healing

Stefan Schultze-Mosgau, Markus B. Blatz, Falk Wehrhan, Karl Andreas Schlegel, Michael Thorwart, Stefan Holst

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The long-term clinical and esthetic success of implant-supported restorations is determined by osseointegration and optimal remodeling of peri-implant soft tissues. Complications of soft-tissue management are often caused by fibrotic regeneration of oral mucosa after multiple surgical procedures. Knowledge of the proliferative processes in wound healing is necessary to attain adequate soft-tissue conditions. Successful reconstruction of peri-implant soft tissues is feasible even in fibrotic conditions when appropriate surgical techniques are selected. The pleiotropic proliferative cytokine TGF-β is involved in the regulation of all phases of wound healing and tissue remodeling. The isoform TGF-β1 is a cytokine associated with the development of fibrotic tissue. Overexpression of TGF-β1 causes scarring and fibrosis, and results in limited clinical success of intraoral soft-tissue management. Experimental therapeutic approaches with neutralizing antibodies to block TGF-β1 resulted in less scarring and a reduction of fibrosis. Further molecular biologic research of cell-matrix-cytokine interactions in wound healing will provide highly specific antifibrotic therapeutic approaches in the future.

Original languageEnglish (US)
Pages (from-to)759-769
Number of pages11
JournalQuintessence international
Issue number10
StatePublished - Nov 1 2005


  • Fibrosis
  • Implants
  • Soft tissue
  • Transforming growth factor-beta
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)


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