TY - JOUR
T1 - Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
AU - Ashrafizadeh, Milad
AU - Zarrabi, Ali
AU - Hushmandi, Kiavash
AU - Hashemi, Farid
AU - Rahmani Moghadam, Ebrahim
AU - Raei, Mehdi
AU - Kalantari, Mahshad
AU - Tavakol, Shima
AU - Mohammadinejad, Reza
AU - Najafi, Masoud
AU - Tay, Franklin R.
AU - Makvandi, Pooyan
N1 - Publisher Copyright:
©
PY - 2020/12/14
Y1 - 2020/12/14
N2 - Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, co-delivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.
AB - Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, co-delivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.
KW - anticancer therapy
KW - chemotherapy
KW - co-delivery platforms
KW - nanocarriers
KW - natural products
KW - small interfering RNA
UR - http://www.scopus.com/inward/record.url?scp=85096008772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096008772&partnerID=8YFLogxK
U2 - 10.1021/acscombsci.0c00099
DO - 10.1021/acscombsci.0c00099
M3 - Article
C2 - 33095554
AN - SCOPUS:85096008772
SN - 2156-8952
VL - 22
SP - 669
EP - 700
JO - Journal of Combinatorial Chemistry
JF - Journal of Combinatorial Chemistry
IS - 12
ER -
