Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women

Sherene S. Min; Amanda H. Corbett; Naser Rezk; Susan Cu-Uvin; Susan A. Fiscus; Leslie Petch; Myron S. Cohen; Angela D.M. Kashuba

doi:10.1097/00126334-200412150-00008

Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women

Sherene S. Min
, Amanda H. Corbett
, Naser Rezk
, Susan Cu-Uvin
, Susan A. Fiscus
, Leslie Petch
, Myron S. Cohen
, Angela D.M. Kashuba

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and post-exposure prophylaxis regimens. This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution. Of 8 ARVs, CVF concentrations ranged from <10% to >100% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary.

Original language	English (US)
Pages (from-to)	1577-1580
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes (1999)
Volume	37
Issue number	5
DOIs	https://doi.org/10.1097/00126334-200412150-00008
State	Published - Dec 15 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antiretroviral concentration
Female genital tract
HIV-1
Nonnucleoside reverse transcriptase inhibitor
Pharmacokinetic
Protease inhibitor

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

Access to Document

10.1097/00126334-200412150-00008

Cite this

Min, S. S., Corbett, A. H., Rezk, N., Cu-Uvin, S., Fiscus, S. A., Petch, L., Cohen, M. S., & Kashuba, A. D. M. (2004). Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women. Journal of Acquired Immune Deficiency Syndromes (1999), 37(5), 1577-1580. https://doi.org/10.1097/00126334-200412150-00008

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title = "Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women",

abstract = "The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and post-exposure prophylaxis regimens. This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution. Of 8 ARVs, CVF concentrations ranged from <10\% to >100\% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary.",

keywords = "Antiretroviral concentration, Female genital tract, HIV-1, Nonnucleoside reverse transcriptase inhibitor, Pharmacokinetic, Protease inhibitor",

author = "Min, \{Sherene S.\} and Corbett, \{Amanda H.\} and Naser Rezk and Susan Cu-Uvin and Fiscus, \{Susan A.\} and Leslie Petch and Cohen, \{Myron S.\} and Kashuba, \{Angela D.M.\}",

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AU - Min, Sherene S.

AU - Corbett, Amanda H.

AU - Rezk, Naser

AU - Cu-Uvin, Susan

AU - Fiscus, Susan A.

AU - Petch, Leslie

AU - Cohen, Myron S.

AU - Kashuba, Angela D.M.

PY - 2004/12/15

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N2 - The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and post-exposure prophylaxis regimens. This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution. Of 8 ARVs, CVF concentrations ranged from <10% to >100% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary.

AB - The pharmacokinetics of antiretrovirals (ARVs) in the female genital tract (FGT) are likely to influence vertical and sexual transmission of HIV, the development of viral resistance, and post-exposure prophylaxis regimens. This study is the first to compare ARV concentrations in direct aspirates of cervicovaginal fluid (CVF) and blood plasma (BP). This unique method provides direct assessment of concentrations without the confounding of cervicovaginal lavage dilution. Of 8 ARVs, CVF concentrations ranged from <10% to >100% of BP concentrations. These large differences in CVF penetration suggest that further research into ARV pharmacokinetics and drug efficacy in the FGT is necessary.

KW - Antiretroviral concentration

KW - Female genital tract

KW - HIV-1

KW - Nonnucleoside reverse transcriptase inhibitor

KW - Pharmacokinetic

KW - Protease inhibitor

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Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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