TY - JOUR
T1 - Protective effect of Solanum nigrum leaves extract on immobilization stress induced changes in rat's brain
AU - Zaidi, Syed Kashif
AU - Hoda, Md Nasrul
AU - Tabrez, Shams
AU - Ansari, Shakeel Ahmed
AU - Jafri, Mohammad Alam
AU - Shahnawaz Khan, Mohd
AU - Hasan, Shirin
AU - Alqahtani, Mohammed H.
AU - Mohammed Abuzenadah, Adel
AU - Banu, Naheed
PY - 2014
Y1 - 2014
N2 - The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se.
AB - The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se.
UR - http://www.scopus.com/inward/record.url?scp=84896138867&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896138867&partnerID=8YFLogxK
U2 - 10.1155/2014/912450
DO - 10.1155/2014/912450
M3 - Article
AN - SCOPUS:84896138867
SN - 1741-427X
VL - 2014
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 912450
ER -