Protein kinase C isoforms in neutrophil adhesion and activation

Anna Bertram, Klaus Ley

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Neutrophils are the first line of defense against bacterial and mycotic pathogens. In order to reach the pathogens, neutrophils need to transmigrate through the vascular endothelium and migrate to the site of infection. Defense strategies against pathogens include phagocytosis, production and release of oxygen radicals through the oxidative burst, and degranulation of antimicrobial and inflammatory molecules. Protein kinase C (PKC)-δ is required for full assembly of NADPH oxidase and activation of the respiratory burst. Neutrophils also express PKC-α and -β, which may be involved in adhesion, degranulation and phagocytosis, but the evidence is not conclusive yet. This review focuses on the potential impact of protein kinase C isoforms on neutrophil adhesion and activation.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • Adhesion
  • Integrin activation
  • NADPH oxidase
  • Neutrophil
  • Protein kinase C
  • Rolling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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