Abstract
Cell-cell interactions mediating leukocyte recruitment and inflammation are crucial for host defense. Leukocyte recruitment into injured tissue proceeds in a multistep process. The first contact of leukocytes with endothelial cells ("capturing" or "tethering") is mediated by selectins and their counter-receptor P-selectin glycoprotein ligand (PSGL)-1. During capture and rolling, leukocytes collect different inflammatory signals, which can activate various pathways. Integration of these signals leads to leukocyte activation, integrin-mediated arrest, cytoskeleton rearrangement, polarization, and transmigration. PSGL-1 on leukocytes also binds to activated platelets, where P-selectin is expressed at locally high site densities following α-granule fusion with the plasma membrane. Here, we review the signaling functions of PSGL-1 and speculate how the different known signaling events might relate to different phases of leukocyte recruitment.
Original language | English (US) |
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Pages (from-to) | 1119-1124 |
Number of pages | 6 |
Journal | Journal of Leukocyte Biology |
Volume | 86 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2009 |
Externally published | Yes |
Keywords
- Integrins
- P-selectin glycoprotein ligand 1
- Signaling cascade
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology