TY - JOUR
T1 - Pupillary response to cognitive demand in Parkinson's disease
T2 - A pilot study
AU - Kahya, Melike
AU - Moon, Sanghee
AU - Lyons, Kelly E.
AU - Pahwa, Rajesh
AU - Akinwuntan, Abiodun E.
AU - Devos, Hannes
N1 - Funding Information:
The authors acknowledge the contributions of Viswa Gangeddula (University of Kansas Medical Center), Ashwaan Uddin (University of Kansas Medical Center), Kevin Williams (University of Kansas Medical Center) and Mikaela Bell (Rockhurst University) for their help with data collection and entry. This study was funded in part by the American Parkinson's Disease Association (PI: HD), and by the T32HD057850 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (MK).
Publisher Copyright:
© 2018 Kahya, Moon, Lyons, Pahwa, Akinwuntan and Devos.
PY - 2018/4/10
Y1 - 2018/4/10
N2 - Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to examine the pupillary response to cognitive demand in a letter-number sequencing (LNS) task between 16 non-demented individuals with PD (age, median (Q1-Q3): 68 (62-72); 10 males) and 10 control participants (age: 63 (59-67); 2 males), matched for age, education, and Montreal Cognitive Assessment (MOCA) scores. A mixed model analysis was employed to investigate cognitive workload changes as a result of incremental cognitive demand for both groups. As expected, no differences were found in cognitive scores on the LNS between groups. Cognitive workload, exemplified by greater pupil dilation, increased with incremental cognitive demand in both groups (p = 0.003). No significant between-group (p = 0.23) or interaction effects were found (p = 0.45). In addition, individuals who achieved to complete the task at higher letter-number (LN) load responded differently to increased cognitive demand compared with those who completed at lower LN load (p < 0.001), regardless of disease status. Overall, the findings indicated that pupillary response reflects incremental cognitive demand in non-demented people with PD and healthy controls. Further research is needed to investigate the pupillary response to incremental cognitive demand of PD patients with dementia compared to non-demented PD and healthy controls.
AB - Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to examine the pupillary response to cognitive demand in a letter-number sequencing (LNS) task between 16 non-demented individuals with PD (age, median (Q1-Q3): 68 (62-72); 10 males) and 10 control participants (age: 63 (59-67); 2 males), matched for age, education, and Montreal Cognitive Assessment (MOCA) scores. A mixed model analysis was employed to investigate cognitive workload changes as a result of incremental cognitive demand for both groups. As expected, no differences were found in cognitive scores on the LNS between groups. Cognitive workload, exemplified by greater pupil dilation, increased with incremental cognitive demand in both groups (p = 0.003). No significant between-group (p = 0.23) or interaction effects were found (p = 0.45). In addition, individuals who achieved to complete the task at higher letter-number (LN) load responded differently to increased cognitive demand compared with those who completed at lower LN load (p < 0.001), regardless of disease status. Overall, the findings indicated that pupillary response reflects incremental cognitive demand in non-demented people with PD and healthy controls. Further research is needed to investigate the pupillary response to incremental cognitive demand of PD patients with dementia compared to non-demented PD and healthy controls.
KW - Cognitive demand
KW - Non-demented
KW - Parkinson's disease
KW - Pupillary response
KW - Working memory
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U2 - 10.3389/fnagi.2018.00090
DO - 10.3389/fnagi.2018.00090
M3 - Article
AN - SCOPUS:85045768351
SN - 1663-4365
VL - 10
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
IS - APR
M1 - 90
ER -