Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation

Sarah E. Mowry, Maria M. LoTempio, Ahmad Sadeghi, Kevin H. Wang, Marilene B. Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Objective: The purpose of this study was to compare quality of life issues in patients with advanced laryngeal versus oropharyngeal cancer after treatment with chemoradiation. Design: A cohort study of 31 patients with laryngeal or oropharyngeal squamous cell carcinoma treated with chemoradiation completed the University of Washington quality of life instrument version 4 (UW-QOL v4). Statistical analysis was performed with Wilcoxon rank sum and chi-square tests. Setting: Academic tertiary care center. Results: Both groups reported similar impairment in the domains of swallowing, chewing, and taste. Oropharyngeal cancer patients reported significantly worse quality of life in the domain of saliva (P < 0.007). Conclusion: Swallowing, chewing, and taste were adversely affected by chemoradiation for both groups. Oropharyngeal patients experienced significantly worse problems with saliva than laryngeal patients. These patients reported high levels of satisfaction with health-related quality of life issues. Significance: Specific head and neck subsites have different morbidities when treated with primary chemoradiation for advanced tumors.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Issue number4
StatePublished - Oct 2006
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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