TY - JOUR
T1 - Radiation dose effect in locally advanced non-small cell lung cancer
AU - Kong, Feng Ming
AU - Zhao, Jing
AU - Wang, Jingbo
AU - Faivre-Finn, Corrine
PY - 2014
Y1 - 2014
N2 - Radiation is the foundation of treatment for locally advanced non-small cell lung cancer (NSCLC), and as such, optimal radiation dose is essential for successful treatment. This article will briefly review biological considerations of radiation dose and their effect in the context of three-dimensional conformal radiation therapy (3D-CRT) including intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for NSCLC. It will focus on literature review and discussions regarding radiation dose effect in locally advanced NSCLC including potential severe and lethal toxicities of high dose radiation given with concurrent chemotherapy. Potential new approaches for delivering safe and effective doses by individualizing treatment based on functional imaging are being applied in studies such as the PET boost trial and RTOG1106. The RTOG concept of delivering high dose radiation to the more resistant tumors with the use of isotoxic dose prescription and adaptive planning will also be discussed in detail.
AB - Radiation is the foundation of treatment for locally advanced non-small cell lung cancer (NSCLC), and as such, optimal radiation dose is essential for successful treatment. This article will briefly review biological considerations of radiation dose and their effect in the context of three-dimensional conformal radiation therapy (3D-CRT) including intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for NSCLC. It will focus on literature review and discussions regarding radiation dose effect in locally advanced NSCLC including potential severe and lethal toxicities of high dose radiation given with concurrent chemotherapy. Potential new approaches for delivering safe and effective doses by individualizing treatment based on functional imaging are being applied in studies such as the PET boost trial and RTOG1106. The RTOG concept of delivering high dose radiation to the more resistant tumors with the use of isotoxic dose prescription and adaptive planning will also be discussed in detail.
KW - Non-small cell lung cancer (NSCLC)
KW - concurrent chemotherapy
KW - radiation dose
UR - http://www.scopus.com/inward/record.url?scp=84900515819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900515819&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2072-1439.2014.01.23
DO - 10.3978/j.issn.2072-1439.2014.01.23
M3 - Article
AN - SCOPUS:84900515819
SN - 2072-1439
VL - 6
SP - 336
EP - 347
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
IS - 4
ER -