Radiation dose effect in locally advanced non-small cell lung cancer

Feng Ming Kong, Jing Zhao, Jingbo Wang, Corrine Faivre-Finn

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Radiation is the foundation of treatment for locally advanced non-small cell lung cancer (NSCLC), and as such, optimal radiation dose is essential for successful treatment. This article will briefly review biological considerations of radiation dose and their effect in the context of three-dimensional conformal radiation therapy (3D-CRT) including intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for NSCLC. It will focus on literature review and discussions regarding radiation dose effect in locally advanced NSCLC including potential severe and lethal toxicities of high dose radiation given with concurrent chemotherapy. Potential new approaches for delivering safe and effective doses by individualizing treatment based on functional imaging are being applied in studies such as the PET boost trial and RTOG1106. The RTOG concept of delivering high dose radiation to the more resistant tumors with the use of isotoxic dose prescription and adaptive planning will also be discussed in detail.

Original languageEnglish (US)
Pages (from-to)336-347
Number of pages12
JournalJournal of Thoracic Disease
Issue number4
StatePublished - 2014


  • Non-small cell lung cancer (NSCLC)
  • concurrent chemotherapy
  • radiation dose

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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