Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy

Cheng Yu, Long Li, Pei Hu, Yan Yang, Wei Wei, Xin Deng, Lu Wang, Franklin R. Tay, Jingzhi Ma

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Gene therapy provides a promising strategy for curing monogenetic disorders and complex diseases. However, there are challenges associated with the use of viral delivery vectors. The advent of nanomedicine represents a quantum leap in the application of gene therapy. Recent advances in stimulus-responsive nonviral nanocarriers indicate that they are efficient delivery systems for loading and unloading of therapeutic nucleic acids. Some nanocarriers are responsive to cues derived from the internal environment, such as changes in pH, redox potential, enzyme activity, reactive oxygen species, adenosine triphosphate, and hypoxia. Others are responsive to external stimulations, including temperature gradients, light irradiation, ultrasonic energy, and magnetic field. Multiple stimuli-responsive strategies have also been investigated recently for experimental gene therapy.

Original languageEnglish (US)
Article number2100540
JournalAdvanced Science
Issue number14
StatePublished - Jul 21 2021


  • gene therapy
  • nonviral vector
  • stimulus-responsive nanocarriers
  • viral vector

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)


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