Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium

Kimberly R. Spurgeon-Pechman, Deborah L. Donohoe, David L. Mattson, Hayley Lund, Leilani James, David P. Basile

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Recovery of renal function is a well-characterized feature of models of acute renal failure; however, more recent studies have reported a predisposition to chronic renal disease. This study sought to determine the susceptibility to sodium-dependent hypertension following recovery from ischemic acute renal failure. Following ischemia-reperfusion (I/R) injury, rats were allowed to recover for 35 days on a 0.4% salt diet, then were switched to 4.0% salt diet for an additional 28 days. Blood pressure was significantly increased in postischemic rats switched to high-sodium diet at day 35 (19 ± 9 mmHg) compared with postischemic rats maintained on low-sodium diet. Plasma renin activity and creatinine clearance were not affected by I/R injury. The ischemic injury combined with transfer to 4.0% salt diet resulted in marked renal hypertrophy characterized by interstitial cellular deposition, tubular dilation, and enhanced rates of albumin excretion. Glomerular structure was altered in post-I/R rats switched to highsodium diet but not in those maintained on low-sodium diets. When rats were acclimated to high-sodium diet before I/R injury, the early injury was similar to that observed in animals acclimated to lowsodium diet, and these animals progressed rapidly toward chronic kidney disease, as evidenced by advancement of albuminuria. These data suggest that the recovery from acute I/R injury is not complete, compromises Na homeostasis, and predisposes hypertension and secondary renal disease.

Original languageEnglish (US)
Pages (from-to)F269-F278
JournalAmerican Journal of Physiology - Renal Physiology
Issue number1
StatePublished - Jul 2007
Externally publishedYes


  • Blood pressure
  • Ischemia
  • Sodium sensitivity

ASJC Scopus subject areas

  • Physiology
  • Urology


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