Recovery of rat gastric mucosa following single fluoride dosing

R. P. Easmann, D. H. Pashley, N. L. Birdsong, R. V. Mckinney, G. M. Whitford

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Rats' stomachs were intubated with 0.1 N HCl or 100 mM NaF in 0.1 N HCl and excised after 1, 12, 24, 48 h or 7 days for light microscopy. The NaF solution caused erosive injury to the oxyntic glandular mucosa 1 h after application. Progressive stages of recovery were seen at 12, 24 and 48 h after fluoride dosing. Complete recovery was seen 7 days after exposure to fluoride. The kinetics of the recovery process from fluoride injury appear to he similar to those which have been reported for gastric injury produced by other substances.

Original languageEnglish (US)
Pages (from-to)779-792
Number of pages14
JournalJournal of Oral Pathology & Medicine
Issue number10
StatePublished - Nov 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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