Recurrent Metastatic Chordoma to the Liver: A Case Report and Review of the Literature

Thomas E. Dickerson, Asad Ullah, Sathvik Saineni, Sandresh Sultan, Srikar Sama, Intisar Ghleilib, Nikhil G. Patel, Islam A. Elhelf, Nagla Abdel Karim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Chordoma is a rare malignant neoplasm derived from notochordal tissue that primarily affects the axial skeleton. Almost 40% of patients have non-cranial chordoma metastases. The most common metastatic sites are the lungs, bones, lymph nodes, and subcutaneous tissue. We present a 52-year female with a history of sacral chordoma presenting with abdominal fullness, early satiety, and a palpable abdominal mass. Abdominal magnetic resonance imaging (MRI) revealed an isolated, highly vascular-ized, and multilobed liver mass in the left lateral segment. The mass was surgically removed using a clean surgical margin. A histological examination and immunohistochemical staining were consistent with a metastatic chordoma. Two years later, follow-up imaging studies showed a 6.5 × 4.0 × 2.0 cm right liver lesion with multiple lungs, chest wall, pleural, and diaphragmatic lesions. Microscopic-and immunohistochemical staining revealed a recurrent metastatic chordoma. Herein, we present a unique case of metastatic recurrent chordoma in the liver with the involvement of other sites. To the best of our knowledge, no other case of recurrent liver metastasis has been reported.

Original languageEnglish (US)
Pages (from-to)4625-4631
Number of pages7
JournalCurrent Oncology
Issue number7
StatePublished - Jul 2022


  • chordoma
  • magnetic resonance imaging
  • malignant

ASJC Scopus subject areas

  • Oncology


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