Referral and Evaluation for Kidney Transplantation Following Implementation of the 2014 National Kidney Allocation System

Southeastern Kidney Transplant Coalition, Carlos Zayas, Laura Mulloy

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Rationale & Objective: The national kidney allocation system (KAS) implemented in December 2014 in the United States redefined the start of waiting time from the time of waitlisting to the time of kidney failure. Waitlisting has declined post-KAS, but it is unknown if this is due to transplant center practices or changes in dialysis facility referral and evaluation. The purpose of this study was to assess the impact of the 2014 KAS policy change on referral and evaluation for transplantation among a population of incident and prevalent patients with kidney failure. Study Design: Cohort study. Setting & Participants: 37,676 incident (2012-2016) patients in Georgia, North Carolina, and South Carolina identified within the US Renal Data System at 9 transplant centers and followed through December 2017. A prevalent population of 6,079 patients from the same centers receiving maintenance dialysis in 2012 but not referred for transplantation in 2012. Exposure: KAS era (pre-KAS vs post-KAS). Outcome: Referral for transplantation, start of transplant evaluation, and waitlisting. Analytical Approach: Multivariable time-dependent Cox models for the incident and prevalent population. Results: Among incident patients, KAS was associated with increased referrals (adjusted HR, 1.16 [95% CI, 1.12-1.20]) and evaluation starts among those referred (adjusted HR, 1.16 [95% CI, 1.10-1.21]), decreased overall waitlisting (adjusted HR, 0.70 [95% CI, 0.65-0.76]), and lower rates of active waitlisting among those evaluated compared to the pre-KAS era (adjusted HR, 0.81 [95% CI, 0.74-0.90]). Among the prevalent population, KAS was associated with increases in overall waitlisting (adjusted HR, 1.74 [95% CI, 1.15-2.63]) and active waitlisting among those evaluated (adjusted HR, 2.01 [95% CI, 1.16-3.49]), but had no significant impact on referral or evaluation starts among those referred. Limitations: Limited to 3 states, residual confounding. Conclusions: In the southeastern United States, the impact of KAS on steps to transplantation was different among incident and prevalent patients with kidney failure. Dialysis facilities referred more incident patients and transplant centers evaluated more incident patients after implementation of KAS, but fewer evaluated patients were placed onto the waitlist. Changes in dialysis facility and transplant center behaviors after KAS implementation may have influenced the observed changes in access to transplantation.

Original languageEnglish (US)
Pages (from-to)707-717
Number of pages11
JournalAmerican Journal of Kidney Diseases
Volume80
Issue number6
DOIs
StatePublished - Dec 2022

Keywords

  • Allocation time
  • health care access
  • health care policy
  • kidney allocation policy (KAS)
  • kidney failure
  • kidney transplantation
  • transplant referral
  • waitlisting

ASJC Scopus subject areas

  • Nephrology

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