Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: A case series

Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Although histopathology is the time-honored gold standard diagnostic measure in dermatology, several factors may detract from an accurate microscopic diagnosis. Limiting factors include: human error, suboptimal biopsy-site selection or biopsy technique, and inherent restrictions of vertical tissue sectioning that lead to incomplete microscopic evaluation of the lesion. Reflectance confocal microscopy (RCM) is a non-invasive imaging tool that allows for the cellular-level examination of the lesion, at a horizontal plane, which may complement the subsequent vertical histopathological tissue examination. Herein, we report a case series whereby prebiopsy RCM examination enhanced the accuracy of histopathological diagnosis or allowed for a critical appraisal of initial histopathological misdiagnosis.

Original languageEnglish (US)
Pages (from-to)830-838
Number of pages9
JournalJournal of Cutaneous Pathology
Volume46
Issue number11
DOIs
StatePublished - Nov 1 2019
Externally publishedYes

Keywords

  • basal cell carcinoma
  • confocal microscopy
  • histopathology
  • melanoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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