TY - JOUR
T1 - Regional pulmonary blood flow during rest, tilt, and exercise in unanesthetized dogs
AU - Parker, J. C.
AU - Ardell, J. L.
AU - Hamm, C. R.
AU - Barman, S. A.
AU - Coker, P. J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - We assessed the heterogeneity of regional pulmonary blood flow (PBF(r)), using radioactive microspheres in five unanesthetized dogs standing at rest (Rest), standing at a 45° upward tilt (Tilt), and during moderate treadmill exercise (Exer). The excised lungs were cut into 1-cm3 pieces along transverse, horizontal, and longitudinal planes. Mean PBF(r) increased from 23.3 ml · min-1 · g-1 at Rest to 57.4 ml · min-1 · g-1 during Exer, but the relative dispersions were not statistically different between states (47.3-51.9%). A small but significant gravity-dependent gradient in PBF(r) of ≤4.7%/cm (r2 ≤ 0.118) as well as a PBF(r) decreasing radial gradient from the lung midpoint of ≤7.2%/cm (r2 ≤ 0.108) were present in all states. PBF(r) at Rest was highly correlated with those at Tilt (r2 = 0.773) and Exer (r2 = 0.888), and a variable PBF, gradient of ≤2.5%/cm from base to apex was observed. Fractal dimensions calculated using relative dispersion as a function of aggregated sample size were not significantly different between states and were 1.132 (r2 = 0.987) at Rest, 1.121 (r2 = 0.973) at Tilt, and 1.149 (r2 = 0.986) during Exer. Thus, gravity and centripetal gradients consistently accounted for a maximal difference of only about twofold in PBF, and <11% of overall PBF(r) heterogeneity in 1-cm3 samples. Recursive anatomic branching of pulmonary arteries and local mechanical factors apparently account for most of the blood flow heterogeneity in small pieces of lung.
AB - We assessed the heterogeneity of regional pulmonary blood flow (PBF(r)), using radioactive microspheres in five unanesthetized dogs standing at rest (Rest), standing at a 45° upward tilt (Tilt), and during moderate treadmill exercise (Exer). The excised lungs were cut into 1-cm3 pieces along transverse, horizontal, and longitudinal planes. Mean PBF(r) increased from 23.3 ml · min-1 · g-1 at Rest to 57.4 ml · min-1 · g-1 during Exer, but the relative dispersions were not statistically different between states (47.3-51.9%). A small but significant gravity-dependent gradient in PBF(r) of ≤4.7%/cm (r2 ≤ 0.118) as well as a PBF(r) decreasing radial gradient from the lung midpoint of ≤7.2%/cm (r2 ≤ 0.108) were present in all states. PBF(r) at Rest was highly correlated with those at Tilt (r2 = 0.773) and Exer (r2 = 0.888), and a variable PBF, gradient of ≤2.5%/cm from base to apex was observed. Fractal dimensions calculated using relative dispersion as a function of aggregated sample size were not significantly different between states and were 1.132 (r2 = 0.987) at Rest, 1.121 (r2 = 0.973) at Tilt, and 1.149 (r2 = 0.986) during Exer. Thus, gravity and centripetal gradients consistently accounted for a maximal difference of only about twofold in PBF, and <11% of overall PBF(r) heterogeneity in 1-cm3 samples. Recursive anatomic branching of pulmonary arteries and local mechanical factors apparently account for most of the blood flow heterogeneity in small pieces of lung.
KW - fractal model
KW - pulmonary circulation
KW - pulmonary edema
KW - radioactive microspheres
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U2 - 10.1152/jappl.1995.78.3.838
DO - 10.1152/jappl.1995.78.3.838
M3 - Article
C2 - 7775327
AN - SCOPUS:0028956494
SN - 8750-7587
VL - 78
SP - 838
EP - 846
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 3
ER -