Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

Jutong Si; Michael Tanowitz; Sandra Won; Lin Mei

doi:10.1016/S0024-3205(98)00096-4

Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

Jutong Si, Michael Tanowitz, Sandra Won, Lin Mei

Graduate Studies

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10 Scopus citations

Abstract

Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.

Original language	English (US)
Pages (from-to)	1497-1502
Number of pages	6
Journal	Life sciences
Volume	62
Issue number	17-18
DOIs	https://doi.org/10.1016/S0024-3205(98)00096-4
State	Published - Mar 27 1998

Keywords

AChR
ARIA
Neuromuscular junction
Transcription

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(98)00096-4

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title = "Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction",

abstract = "Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.",

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T1 - Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

AU - Si, Jutong

AU - Tanowitz, Michael

AU - Won, Sandra

AU - Mei, Lin

PY - 1998/3/27

Y1 - 1998/3/27

N2 - Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.

AB - Transcription of genes encoding nicotinic acetylcholine receptor (AChR) subunits (α, β, γ or ε, and δ) is highest in nuclei localized to the synaptic region of the muscle which contributes to maintain a high density of AChRs at the postjunctional membrane. ARIA (AChR inducing activity) is believed to be the trophic factor utilized by motor neurons to stimulate AChR synthesis in the subsynaptic area. ARIA stimulates tyrosine phosphorylation of the erbB proteins and activates the MAP kinase pathway which is required for the ARIA-mediated induction of AChR genes.

KW - AChR

KW - ARIA

KW - Neuromuscular junction

KW - Transcription

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JO - Life Sciences

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ER -

Regulation by ARIA/neuregulin of acetylcholine receptor gene transcription at the neuromuscular junction

Abstract

Keywords

ASJC Scopus subject areas

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