Regulation of Aldosterone Production

Silvia Monticone, William E. Rainey, Wendy B. Bollag, Carlos M. Isales

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Aldosterone represents the major mineralocorticoid hormone in all mammals. It is synthesized in the outer layer of the adrenal cortex, called the zona glomerulosa, and plays a pivotal role in the regulation of blood pressure and electrolyte homeostasis, through the absorption of sodium and water. Aldosterone production is tightly regulated through the selective expression in the zona glomerulosa of CYP11B2, encoding aldosterone synthase, and the centripetal blood flow in the adrenal cortex, which prevents the precursors of aldosterone in the zona fasciculata from accessing aldosterone synthase. The main physiological stimuli of aldosterone secretion are angiotensin II, potassium, and adrenocorticotropin. Aldosterone production can be regulated acutely (within minutes of stimulation), by increased expression and phosphorylation of the steroidogenic acute regulatory protein (StAR), and chronically (hours to days) through increased expression of CYP11B2.

Original languageEnglish (US)
Title of host publicationTextbook of Nephro-Endocrinology
PublisherElsevier Inc.
Pages429-449
Number of pages21
ISBN (Electronic)9780128032473
DOIs
StatePublished - Jan 1 2009

Keywords

  • Aldosterone
  • Angiotensin II
  • ATP1A1
  • ATP2B3
  • CACNA1D
  • CYP11B2
  • KCNJ5
  • Phospholipase C
  • Phospholipase D

ASJC Scopus subject areas

  • General Medicine

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