Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo

T. Ahmed; S. Frey; J. U. Frey

doi:10.1016/j.neuroscience.2004.01.005

Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo

T. Ahmed, S. Frey, J. U. Frey

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Hippocampal long-term potentiation (LTP) is the most prominent cellular model underlying learning and memory formation. However, which cellular processes are involved in maintaining LTP remains largely unknown. We have previously detailed temporal modulations of cyclic adenosine monophosphate (cAMP) and a cAMP-specific phosphodiesterase, PDE4B3, after LTP-induction and its maintenance in hippocampal area CA1 in vitro. To test whether other hippocampal sub-structures are characterised by similar mechanisms, tissue from the area dentata of freely moving rats was analysed at different LTP-time points. The tissue was fractionated into three components, where PDE4B-levels and cAMP-concentrations were measured. In contrast with data obtained in area CA1 [Neuroscience 117 (2003) 627], we now detail an LTP-specific translational, but not transcriptional regulation of PDE4B3 within the first 8 h after tetanization and present spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific.

Original language	English (US)
Pages (from-to)	857-867
Number of pages	11
Journal	Neuroscience
Volume	124
Issue number	4
DOIs	https://doi.org/10.1016/j.neuroscience.2004.01.005
State	Published - 2004

Keywords

3-isobutyl-1-methyl-2, 6(1H,3H)-purinedione
Area dentata
CREB
DG
Dentate gyrus
GFAP
Glial fibrillary acidic protein
Hippocampus
IBMX
LFS
Learning
Long-term potentiation
Memory formation
Phosphodiesterase PDE4B3
cAMP response element binding protein

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuroscience.2004.01.005

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title = "Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo",

abstract = "Hippocampal long-term potentiation (LTP) is the most prominent cellular model underlying learning and memory formation. However, which cellular processes are involved in maintaining LTP remains largely unknown. We have previously detailed temporal modulations of cyclic adenosine monophosphate (cAMP) and a cAMP-specific phosphodiesterase, PDE4B3, after LTP-induction and its maintenance in hippocampal area CA1 in vitro. To test whether other hippocampal sub-structures are characterised by similar mechanisms, tissue from the area dentata of freely moving rats was analysed at different LTP-time points. The tissue was fractionated into three components, where PDE4B-levels and cAMP-concentrations were measured. In contrast with data obtained in area CA1 [Neuroscience 117 (2003) 627], we now detail an LTP-specific translational, but not transcriptional regulation of PDE4B3 within the first 8 h after tetanization and present spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific.",

keywords = "3-isobutyl-1-methyl-2, 6(1H,3H)-purinedione, Area dentata, CREB, DG, Dentate gyrus, GFAP, Glial fibrillary acidic protein, Hippocampus, IBMX, LFS, Learning, Long-term potentiation, Memory formation, Phosphodiesterase PDE4B3, cAMP response element binding protein",

author = "T. Ahmed and S. Frey and Frey, {J. U.}",

note = "Funding Information: We would like to thank Dr. T. Behnisch and Mrs. J. Leutgeb for assistance with confocal microscopy and Mrs. G. Behnisch for her excellent technical assistance. This work was supported by the German DFG SFB 426: “Limbic Structures and Functions” (TP B6) to J.U.F.",

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language = "English (US)",

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T1 - Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo

AU - Ahmed, T.

AU - Frey, S.

AU - Frey, J. U.

N1 - Funding Information: We would like to thank Dr. T. Behnisch and Mrs. J. Leutgeb for assistance with confocal microscopy and Mrs. G. Behnisch for her excellent technical assistance. This work was supported by the German DFG SFB 426: “Limbic Structures and Functions” (TP B6) to J.U.F.

PY - 2004

Y1 - 2004

N2 - Hippocampal long-term potentiation (LTP) is the most prominent cellular model underlying learning and memory formation. However, which cellular processes are involved in maintaining LTP remains largely unknown. We have previously detailed temporal modulations of cyclic adenosine monophosphate (cAMP) and a cAMP-specific phosphodiesterase, PDE4B3, after LTP-induction and its maintenance in hippocampal area CA1 in vitro. To test whether other hippocampal sub-structures are characterised by similar mechanisms, tissue from the area dentata of freely moving rats was analysed at different LTP-time points. The tissue was fractionated into three components, where PDE4B-levels and cAMP-concentrations were measured. In contrast with data obtained in area CA1 [Neuroscience 117 (2003) 627], we now detail an LTP-specific translational, but not transcriptional regulation of PDE4B3 within the first 8 h after tetanization and present spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific.

AB - Hippocampal long-term potentiation (LTP) is the most prominent cellular model underlying learning and memory formation. However, which cellular processes are involved in maintaining LTP remains largely unknown. We have previously detailed temporal modulations of cyclic adenosine monophosphate (cAMP) and a cAMP-specific phosphodiesterase, PDE4B3, after LTP-induction and its maintenance in hippocampal area CA1 in vitro. To test whether other hippocampal sub-structures are characterised by similar mechanisms, tissue from the area dentata of freely moving rats was analysed at different LTP-time points. The tissue was fractionated into three components, where PDE4B-levels and cAMP-concentrations were measured. In contrast with data obtained in area CA1 [Neuroscience 117 (2003) 627], we now detail an LTP-specific translational, but not transcriptional regulation of PDE4B3 within the first 8 h after tetanization and present spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific.

KW - 3-isobutyl-1-methyl-2, 6(1H,3H)-purinedione

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KW - DG

KW - Dentate gyrus

KW - GFAP

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KW - Hippocampus

KW - IBMX

KW - LFS

KW - Learning

KW - Long-term potentiation

KW - Memory formation

KW - Phosphodiesterase PDE4B3

KW - cAMP response element binding protein

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ER -

Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo

Abstract

Keywords

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